What is Oxidative Stress?
Oxidative stress is an imbalance between free radicals and antioxidants in your body. Free radicals are oxygen-containing molecules with an uneven number of electrons. The uneven number allows them to easily react with other molecules. Free radicals can cause large chain chemical reactions in your body because they react so easily with other molecules. These reactions are called oxidation. They can be beneficial or harmful.
Effects of Oxidative Stress the on Body
Oxidation is a normal and necessary process that takes place in your body. Oxidative stress, on the other hand, occurs when there’s an imbalance between free radical activity and antioxidant activity. When functioning properly, free radicals can help fight off pathogens. Pathogens lead to infections. When there are more free radicals present than can be kept in balance by antioxidants, the free radicals can start doing damage to fatty tissue, DNA, and proteins in your body. Proteins, lipids, and DNA make up a large part of your body so that damage can lead to a vast number of diseases over time. These include: Diabetes Atherosclerosis, or the Hardening of the Blood Vessels Inflammatory Conditions High Blood Pressure, Which is Also Known as Hypertension Heart Disease Neurodegenerative Diseases, Such as Parkinson’s and Alzheimer’s Cancer
What is Nrf2?
What is Nrf2?
Nrf2 is a powerful protein that is latent within each cell in the body, unable to move or operate until it is released by an Nrf2 activator. Once released it migrates into the cell nucleus and bonds to the DNA at the location of the Antioxidant Response Element (ARE) or also called hARE (Human Antioxidant Response Element) which is the master regulator of the total antioxidant system that is available in ALL human cells. This balancing act can become disrupted as one age, or if the body is overcome by malfunction and disease resulting in further cellular damage. This damage is known as oxidative stress and is accompanied by free radical production. Oxidative stress and the associated free radical damage contributes to the progression of hundreds of diseases and aging symptoms.
GenOxidil and Nrf2
GenOxidil reduces oxidative stress in humans by an average of 40% in 30 days. Genoxidil is a high-tech product designed to nourish and stimulate the Nrf2 protein of our body, cellular stress is inevitable for everyone, Genoxidil helps regulate survival genes. Activator of the Nrf2 Protein. 5 Systems. Many benefits for you … With more than 50 100% Natural Phytonutrients. The human being is formed by more than 100 trillion cells and each of them requires the best nutrients to be healthy.
When the body is young and healthy it is able to take care of the balance between cellular damage and repair and rejuvenation. One way the body takes care of repairing the damage is to signal the production of antioxidant enzymes or survival genes through something known as the Nrf2 pathway.
GenOxidil Works in 5 Different Levels
Cellular Nutrition System.
Nrf2 Activators as Attractive Therapeutics for Diabetic Nephropathy
Diabetes is the major cause of chronic kidney disease worldwide (1) with treatment options focused primarily on glucose control, blood pressure, lipid lowering, and the blockade of the renin-angiotensin system (2). However, despite intensive metabolic control and other interventions (3), the unrelenting decline in kidney function means that for many patients the condition progresses to overt kidney failure. This underpins the urgent need for novel approaches to manage the ever-increasing number of patients with diabetes and chronic kidney disease.
One approach that is attracting attention is the use of compounds to bolster the natural cytoprotective responses of the body. The transcription factor NF-E2–related factor 2 (Nrf2), together with its negative regulator, Kelch-like ECH-associated protein 1 (Keap1), is considered one of the most important cellular defense mechanisms to combat oxidative stress (4) with a particular role in the regulation of phase II detoxifying enzymes (Fig. 1). In particular, NADPH quinone oxidoreductase, glutathione S-transferase, heme oxygenase-1, and γ-glutamylcysteine synthetase are well-studied targets of Nrf2 that are upregulated through the antioxidant response element found in the promoters of these genes (5). Therefore, the coordinated upregulation of genes coding for detoxification, antioxidant, and anti-inflammatory regulators is seen as a potential therapeutic strategy to protect against insults such as inflammation and oxidative stress that are known to be enhanced by the diabetic milieu.
It is therefore not surprising that attention has focused on identifying small molecule activators of the Nrf2/Keap1 pathway. Many chemically diverse activators have already been identified (6), including the glutathione peroxidase-1 mimetic ebselen (7), sulforaphane found in cruciferous vegetables (8), caffeic acid phenethylester from the bee product propolis (9), cinnamic aldehyde (found in cinnamon bark), and most recently, bardoxolone methyl (10,11). Many have shown promising actions relevant to diabetes complications.
Telomeres with Astragalus.
Telomeres with Astragalus
Telomerase activators – Lengthening Telomeres with Astragalus. The word telomere comes from the Greek words telos (end) and meros (part). It is a region of repeating nucleotide sequences at the base of each chromatid. Chromatids are pairs of chromosome strands that form when chromosomes divide in half and copy themselves. Telomeres are not invincible; however, over time they shorten in length and deteriorate leading to aging effects on the cells and the human body.
Telomerase activators –
Lengthening Telomeres with Astragalus. The word telomere comes from the Greek words telos (end) and meros (part). It is a region of repeating nucleotide sequences at the base of each chromatid. Chromatids are pairs of chromosome strands that form when chromosomes divide in half and copy themselves. Telomeres are not invincible; however, over time they shorten in length and deteriorate leading to aging effects on the cells and the human body.
The Discovery of Telomeres
Telomeres were not discovered until the 1970s when the Russian biologist Alexei Olovnikov first noticed that during cell division chromatids could not completely replicate the material at their bases. What they noted was that the length of each individual telomere chain was directly responsible for the number of cell divisions each cell could undergo, or how long it could live.
‘Telomeres’ Role in Aging
Telomeres in human blood are extremely important to aging. At birth, they tend to be around 8,000 base pairs long, around 35 years they are 3,000 base pairs long and by age 65 they can be less than 1,500 base pairs long. Cells usually divide between 50 and 70 times in a lifetime and during each division 20 to 300 telomere base pairs are lost. Telomere length varies from person to person at any given age. When studied, subjects aged 65 who had less telomere base pairs than other subjects of the same age were more likely to die of heart disease or cancer.
Environmental factors affect telomere length
Stress, diet, and lifestyle also play key roles in telomere length. When we are under stress, our cells respond, and telomeres shorten. For instance, one study found that women with chronically ill children had dramatically shorter telomere chains than those of women with low-stress children. Anxiety, depression and other mental states play a huge part in telomere and cellular health. Through lifestyle changes, people can both increase telomere length and protect existent telomeres from further damage. They first noticed that during cell division chromatids could not completely replicate the material at their bases. What they noted was that the length of each individual telomere chain was directly responsible for the number of cell divisions each cell could undergo, or how long it could live.
Over 75 Percent of people who used this supplement reported that they noticed an improvement in their skin and immune system function. Over 50 percent saw an improvement in vision, libido, and quality of sleep.TA-65 is a documented telomerase activator in animals. Its active ingredient is a naturally occurring polymer that activates the hTERT, which in turn activates the enzyme telomerase.
Telomerase, as previously stated, inhibits telomeres from shortening and TA-65 is also said to increase overall telomere length. TA-65 is actually an extract of Astragalus propinquus, which is also available in a tablet in GenOxidil as a telomere support supplement. Astragalus extract has been used in some parts of China for centuries as an herbal supplement. It is now a known telomerase activator but only when used in very high concentrations.
For hundreds of years, shiitake mushrooms have been a popular food source in Asia. They’re the second most popular and the third most widely cultivated edible mushroom in the world. Today, shiitakes can be found in most grocery stores because of their meaty and versatile flavor, but did you know that they’re packed with B vitamins and have the power to fight cancer cells, cardiovascular disease and infections? That’s just a few of shiitake mushroom nutrition benefits. Why are these small fungi so powerful? It’s because shiitake mushrooms have antiviral, antibacterial and antifungal properties. They also help to control blood sugar levels and reduce inflammation within the body. That’s right — all of these health benefits come from eating a mushroom. And there are a ton of easy ways to incorporate shiitake mushrooms into your diet.
8 Scientifically Proven Benefits
Shiitake mushrooms contain many chemical compounds that protect your DNA from oxidative damage, which is partly why they’re so beneficial. Lentinan, for example, heals chromosome damage caused by anticancer treatments. Eritadenine substances help reduce cholesterol levels and support cardiovascular health. Researchers at Shizuoka University in Japan found that eritadenine supplementation significantly decreased plasma cholesterol concentration. (1) Shiitakes are also unique for a plant because they contain all eight essential amino acids, along with a type of essential fatty acid called linoleic acid. Linoleic acid helps with weight loss and building muscle. It also has bone-building benefits, improves digestion, and reduces food allergies and sensitivities.
1. Fight Obesity
Certain components of the shiitake mushroom have hypolipidaemic (fat-reducing) effects, such as eritadenine and b-glucan, a soluble dietary fiber that’s also found in barley, rye, and oats. Studies have reported that b-glucan can increase satiety, reduce food intake, delay nutrition absorption and reduce plasma lipid (fat) levels. A 2011 study published in the Journal of Obesity examined the effects of shiitake mushrooms on plasma lipid profiles, fat dispositions, energy efficiency, and body fat index. Rats were fed a high-fat diet for a six-week period. Researchers found significant effects of dietary intervention on body weight gain. Rats on a high dose of shiitake mushroom diet (which involved adding mushroom powder to a high-fat diet) had 35 percent lower body weight gains than rats on low and medium shiitake mushroom diets. Rats on the high dose shiitake mushroom diet also had significantly lower total fat masses and had a trend of lower fat accumulation. The researchers concluded by suggesting that shiitake mushrooms can help prevent body weight gain, fat deposition, and plasma triacylglycerol when added to a high-fat diet. This encourages an effort to pursue human studies that examine the efficacy of shiitake mushrooms for the prevention and treatment of obesity and related metabolic disorders.
2. Support Immune Function
Mushrooms have the ability to boost the immune system and combat many diseases by way of providing important vitamins, minerals and enzymes. A 2015 study published in the Journal of the American College of Nutrition evaluated 52 healthy males and females, aged 21–41 years, to determine if shiitake mushrooms could improve human immune function. The study involved a four-week parallel group trial that involved participants consuming either five or 10 grams of mushrooms daily. The results suggest that consuming mushrooms improved cell effector function and improved gut immunity. There was also a reduction of inflammation due to mushroom consumption.
3. Destroy Cancer Cells
Research suggests that shiitake mushrooms help fight cancer cells and the lentinan in shiitakes help heal chromosome damage caused by anticancer treatments. This suggests shiitakes could be used as a potential natural cancer treatment. A 2006 study published in the Journal of Alternative and Complementary Medicine investigated the potential roles of an ethyl acetate fraction from shiitake mushrooms. The study involved two human breast carcinoma cell lines, one human nonmalignant breast epithelial cell line and two myeloma cell lines. The results suggest that shiitake mushrooms were able to inhibit growth in tumor cells with their mycochemical value. Shiitake mushroom successfully inducted apoptosis, the process of programmed cell death.
4. Support Cardiovascular Health
Shiitake mushrooms have sterol compounds that interfere with the production of cholesterol in the liver. They also contain potent phytonutrients that help keep cells from sticking to blood vessel walls and forming plaque buildup, which maintains healthy blood pressure and improves circulation. A study conducted at Tohoku University in Japan found that shiitake mushrooms prevented blood pressure increase in hypertensive rats. Shiitake feeding resulted in a decrease in VLDL and HDL cholesterol, whereas maitake mushroom feeding caused a decrease in VLDL cholesterol only.
5. Contain Antimicrobial Properties
A 2011 study at the UCL Eastman Dental Institute in London tested shiitake’s antimicrobial effects on gingivitis, a preventable disease that involves inflammation of the gums due to the buildup of a microbial biofilm at the gingival margin. The effectiveness of shiitake mushrooms was compared to that of the active component in the leading gingivitis mouthwash, containing chlorhexidine.
The total bacterial numbers, as well as the numbers of eight key organisms in the oral community, were investigated after treatment. The results indicated that shiitake mushroom extract lowered the numbers of some pathogenic organisms without affecting the organisms associated with health, unlike chlorhexidine, which had a limited effect on all organisms
6. Boost Energy and Brain Function
Shiitake mushrooms are a great source of B vitamins, which help support adrenal function and turn nutrients from food into useable energy. They also help balance hormones naturally and break through the brain fog to maintain focus all day long — even improving cognitive performance.
Millions of Americans come up short on one or more of the B vitamins, and that causes energy slumps, unhealthy blood cell and adrenal effects, and foggy thinking. Adding shiitake mushrooms to your diet can give you the extra boost of B vitamins that you need to avoid a deficiency.
7. Provide Vitamin D
Although vitamin D is best obtained from the sun, shiitake mushrooms can also provide a decent source of this essential vitamin. Vitamin D is important for bone health as well as reducing the risk of heart disease, diabetes, autoimmune diseases and some types of cancer. It’s vital for the absorption and metabolism of calcium and phosphorus, too.
Getting ample supply of vitamin D also helps regulate and support the immune system, maintain healthy body weight, maintain brain function as you age, reduce the severity of asthma symptoms, reduce the risk of developing rheumatoid arthritis in women, and reduce the risk of developing multiple sclerosis. Mushrooms, as well as wild-caught salmon, raw dairy and eggs, are the best vitamin D-rich foods.
8. Promote Skin Health
When selenium is taken with vitamins A and E, it can help reduce the severity of acne and the scarring that can occur afterward. A hundred grams of shiitake mushrooms contain 5.7 milligrams of selenium, which is 8 percent of your daily value. That means shiitake mushrooms act as a natural acne treatment. In an open trial, 29 patients were given 0.2 milligram of selenium and 10 milligrams of tocopheryl succinate for their acne twice daily for six to 12 weeks. After treatment, the patients noticed positive results. The zinc in shiitake mushrooms also promotes immune function and reduces the build up of DHT to improve skin healing.